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激素替代疗法可减少中风后遗症
http://www.100md.com 2001年7月26日 家庭医生医疗保健网
     路透社旧金山健康消息-研究发现:接受激素替代疗法(HRT)的妇女中风后患永久性智力损伤的可能性较小。

    激素替代疗法是预防妇女更年期后骨质疏松的有效方法,有研究表明这种疗法还可以减少年长妇女心脏病的危险。最近,在美国物理治疗及康复医学协会年度会议上,来自田纳西州查塔努加市康复医院的罗伯特·哈姆斯博士发表了他的研究结果:激素替代疗法可以缓解中风后智力损伤的危险性。

    研究结果是根据对137名妇女的调查得出的。在第一次中风的妇女中,有17%在中风前就已经接受激素替代疗法,这部份妇女的智力测验成绩要比其他没有接受过激素替代疗法的妇女要高。另外,中风前做过子宫切除术的妇女在智能测试中的表现也不错。因为做过子宫切除术的妇女往往接受激素替代疗法。在接受激素替代疗法的病人中,做过子宫切除术的妇女占大多数。这些女性之往往只用雌激素,而不是雌激素加和黄体酮的激素替代疗法。激素替代疗法缓解中风后智力损伤的作用并不受年龄、种族、有无吸烟习惯及其它跟中风有关的因素的影响。
, http://www.100md.com
    目前还不清楚激素替代疗法影响中风后病人智力的原理,可能是雌性激素可以保护记忆力及其它认知能力。最近,哈姆斯博士已经把研究的重点放在了单独使用雌激素或将雌激素和黄体酮一起使用是否会防止女性出现第二次中风。

    Hormone Replacement May Protect Against Stroke Damage

    SAN FRANCISCO (Reuters Health) - Women on hormone replacement therapy (HRT) may be less likely to suffer long-term mental damage after having a stroke, new research suggests.

    HRT is a well-established protector of bone density after menopause, and research has shown it may cut older women‘s risk of heart disease. Still other--although less clear--evidence suggests that hormone replacement wards off stroke and may preserve memory and other mental abilities that decline with age. Now, results of a study of 137 women suggest HRT lessens the blow a stroke can deal to a person‘s mental functioning.
, 百拇医药
    Among women who had had a first-time stroke, the 17% who had been on HRT before their strokes scored higher than other women on tests of mental functioning. The protective effect of HRT was sustained regardless of age, race, smoking habits and other factors that affect stroke risk.

    According to Dr. Robert Harmuth of Siskin Hospital for Physical Rehabilitation in Chattanooga, Tennessee, this research provides more evidence that hormone replacement benefits most postmenopausal women.
, 百拇医药
    Harmuth presented his findings Friday at the annual meeting of the American Academy of Physical Medicine and Rehabilitation.

    Just why HRT would affect mental capacity after a stroke is unclear, Harmuth said. However, it has been suggested that estrogen protects memory and other cognitive abilities, he noted.

    In the current study, women who had undergone a hysterectomy before their strokes also performed better on mental tests. Harmuth said these women were more likely to be receiving estrogen alone, rather than a combination of estrogen and progestin.

    These women also comprised a ``huge percentage‘‘ of those on HRT, Harmuth pointed out. He said the modest number of study patients who had been on HRT was ``appalling.‘‘

    Harmuth is currently studying whether estrogen alone or estrogen plus progestin protects women from having a second stroke., 百拇医药